By Shubham Batra

(Reuters) -European shares edged lower on Wednesday, as investors stayed on the sidelines ahead of an all-important interest rate decision by the U.S. Federal Reserve that could mark the beginning of a monetary-easing cycle in the world’s largest economy.

The pan-European index was down 0.2% at 516.15 points, led by losses in healthcare shares following reports that Novo Nordisk (NYSE:)’s Ozempic is “very likely” to be one of the next drugs targeted for a price cut in the United States.

The Danish drugmaker’s shares were down 1.7%.

Technology shares also pulled the markets down with a 0.7% fall while miners slipped 0.5%.

All major European markets were trading flat to lower.

100 dipped 0.3% after UK headline inflation stood at an annual rate of 2.2% in August, unchanged from July, but price growth in the services sector – closely watched by the Bank of England – picked up.

The day will be monopolised by the U.S. central bank’s expected start of policy easing, with a decision on interest rates due at 1800 GMT. Money markets see a 63% chance of a 50-basis-point reduction, according to CME’s FedWatch Tool.

“Markets currently expect a 50-bps cut by the Fed, and it’s very unlikely the Fed will surprise investors by going 25 bps. We expect the Fed to cut 50 bps to get ahead of downward trending labor market data, even as the inflation fight looks done,” said Sonu Varghese, global macro strategist at Carson Group.

Investors will also keep a close watch on the euro zone’s inflation data at 0900 GMT, while monitoring comments from European Central Bank’s supervisors Claudia Buch and Elizabeth McCaul later in the day.

Italy’s Campari (LON:) slipped 6.1% to the bottom of the benchmark index as CEO Matteo Fantacchiotti unexpectedly stepped down after only five months at the helm.

© Reuters. The German share price index DAX graph is pictured at the stock exchange in Frankfurt, Germany, September 17, 2024.     REUTERS/Staff

Reckitt Benckiser (LON:) advanced 1.3% following reports that the consumer goods giant launched early discussions with potential suitors for a sale of its homecare assets, which could be worth more than 6 billion pounds ($7.89 billion).

France’s Ubisoft Entertainment jumped nearly 5% to the top of STOXX 600 after BMO Capital Markets raised the rating on the stock to “outperform”.

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